Degradation kinetics of larotaxel and identification of its degradation products in alkaline condition

Degradation kinetics of larotaxel and identification of its degradation products in alkaline condition

Larotaxel, a new taxane compound prepared by partial synthesis from 10-deacetyl baccatin III, is active against tumors. In this research, a selective LC-MS method was developed and validated for the study of degradation kinetics of larotaxel, which was carried out in aqueous solutions with different pH (1.5, 3.0, 5.0, 6.5, 7.4, 9.0, 10 and 11.0) and temperature (0, 25, 37 and 45 °C). The linear...

validated stability indicating hplc method for the determination of mebeverine in the presence of its degradation products: kinetics study of its degradation in oxidative condition

Phototransformation of Amlodipine: Degradation Kinetics and Identification of Its Photoproducts

Nowadays, monitoring focuses on the primary compounds and does not include degradation products formed during various biological and chemical processes. Transformation products may have the same effects to human health and the environment or sometimes they can be more toxic than the parent compound. Unfortunately, knowledge about the formation of degradation products is still limited, however, ...

Degradation rates and products of fluticasone propionate in alkaline solutions

The apparent degradation rate constant of fluticasone propionate (FLT) in 0.1 M NaOH:methanol=1:1 at 37 °C was previously reported to be 0.169±0.003 h-1, and four degradation products (products 1-4) were observed in the solution. The aims of the present study were to assess the degradation rates of FLT in other alkaline solutions and clarify the chemical structures of the four degradation produ...

a stability indicating hplc method for determination of mebeverine in the presence of its degradation products and kinetic study of its degradation in oxidative condition

an hplc method for determination of mebeverine hydrochloride (mh) in the presence of its degradation products was developed. the degradation of mh was studied under hydrolysis, oxidative and photolysis stress conditions. under alkaline, acidic and oxidative conditions, degradation of mh was observed. the separation was performed using a symmetry c 18 column and a mixture of 50 mm kh 2 po 4 , ac...